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KMID : 0363220160540040268
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Korean Journal of Dermatology
2016 Volume.54 No. 4 p.268 ~ p.274
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A Study of the Balance of Th17 Cells and Regulatory T Cells in Psoriasis
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Na Chan-Ho
Kim Dong-Jin
Kim Min-Sung
Shin Bong-Seok
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Abstract
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Background: Although the pathogenesis of psoriasis is not fully understood, recent studies suggest that an imbalance of T-helper 17 cells (Th17) and CD4＋CD25＋Foxp3＋ regulatory T cells (Treg) is associated with psoriasis. However, the association between the imbalance of Th17 and Treg cells and psoriasis still remains controversial.
Objective: In this study, the proportion of Th17 and Treg cells from peripheral blood were evaluated in patients with psoriasis and normal controls.
Methods: The proportion of Th17 and Treg cells from peripheral blood were examined by flow cytometry in psoriasis patients (n=20) and age-matched healthy controls (n=23). The correlation between Th17 and Treg cells and the clinical parameters in psoriasis patients were also analyzed.
Results: There were significant increases in the proportion of circulating Th17 cells and the ratio of Th17 to Treg cells in psoriasis patients compared to control (p=0.001 and p=0.002, respectively). In contrast to the Th17 cells, there was no significant difference in the proportion of Treg cells in psoriasis patients compared to control (p=0.310). The ratio of Th17 to Treg cells was positively correlated with body surface area (BSA) (p=0.038). In addition, although the ratio of Th17 to Treg cells increased along with psoriasis area severity index (PASI) score, there was no significant correlation (p=0.062).
Conclusion: These findings show that there exists an imbalance in Th17 and Treg cells in psoriasis, which may contribute to its pathogenesis and involved surface area.
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KEYWORD
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Psoriasis, Regulatory T cells, Th17 cells
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